The villains struck at Crewe's West Street Post Office at 8.35am yesterday, Wednesday.
They pounced just after the two women workers opened up the post office.
Both the suspects, who wore masks, confronted the women and bundled them into the kitchen area locking the door.
The two men then went through the safe, emptying the contents before making their escape, through the back door.
The women were discovered locked in the kitchen when a third member of staff arrived at about 8.50am and raised the alarm.
The two men wore balaclavas and gloves and did not have noticeable accents. No weapons were seen and the two women were shocked but physically uninjured.
Police are appealing for witnesses or anyone who saw something unusual in the area to come forward.
Anyone with any information about the robbery is being urged to get in contact with the Crewe CID office on 01270 500222.
Converted for the new archive on 13 March 2001. Some images and formatting may have been lost in the conversion.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules hereComments are closed on this article